A single residue change only differing by an atomic group can drive imprinting to influenza
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PMID:
Jiayi Sun, Gyunghee Jo, Chloe A Troxell, Yanbin Fu, Robert Hoezl, Huibin Lv, Hassanein H Abozeid, Qi Wen Teo, Tossapol Pholcharee, Joshua J C McGrath, Siriruk Changrob, Sean A Nelson, Atsuhiro Yasuhara, Min Huang, Nai-Ying Zheng, Jordan C Chervin, Lei Li, Monica L Fernández-Quintero, Johannes R Loeffler, Alesandra J Rodriguez, Jiachen Huang, Olivia M Swanson, Angel Balmaseda, Guillermina Kuan, Lora Campredon, E Kaitlynn Allen, Gabriele Neumann, Nicholas C Wu, Yoshihiro Kawaoka, Florian Krammer
Integrative mapping of preexisting influenza immune landscapes predicts vaccine response
J Clin Invest. 2025 Jul 15;135(18):e189300. doi: 10.1172/JCI189300. eCollection 2025 Sep 16.
PMID:
Stephanie Hao, Ivan Tomic, Benjamin B Lindsey, Ya Jankey Jagne, Katja Hoschler, Adam Meijer, Juan Manuel Carreño Quiroz, Philip Meade, Kaori Sano, Chikondi Peno, André G Costa-Martins, Debby Bogaert, Beate Kampmann, Helder Nakaya, Florian Krammer, Thushan I de Silva, Adriana Tomic
Characterization of the glycoproteins of novel fish influenza B-like viruses
bioRxiv [Preprint]. 2025 May 8:2025.05.08.652883. doi: 10.1101/2025.05.08.652883.
PMID:
Gagandeep Singh, Jiachen Huang, Disha Bhavsar, Kirill Vasilev, James A Ferguson, Geert-Jan Boons, Viviana Simon, Robert P de Vries, Julianna Han, Andrew Ward, Florian Krammer
Evaluating Modes of Influenza Transmission (EMIT-2): Insights from a Controlled Human Influenza Virus Infection Transmission Trial (CHIVITT)
medRxiv [Preprint]. 2025 Dec 2:2025.04.28.25326458. doi: 10.1101/2025.04.28.25326458.
PMID:
Jianyu Lai, Hamed Sobhani, Kristen K Coleman, S-H Sheldon Tai, Filbert Hong, Isabel Sierra Maldonado, Yi Esparza, Kathleen M McPhaul, Shengwei Zhu, Don L DeVoe, Justin R Ortiz, Shuo Chen, Temima Yellin, Juan Manuel Carreno, Florian Krammer, Benjamin J Cowling, Aubree Gordon, Wilbur H Chen, Jelena Srebric, Donald K Milton
Purification and characterization of recombinant neuraminidase as a potentially broadly protective influenza virus vaccine candidate
Vaccine. 2025 Aug 30;62:127471. doi: 10.1016/j.vaccine.2025.127471. Epub 2025 Jul 11.
PMID:
Fernando De Mathia, Tobias Kargl, Matthias Müller, Irfan Erdem, Brooks Hayes, Eduard Puente-Massaguer, Florian Krammer, Nico Lingg
Immunogenicity and protective efficacy of an intranasal neuraminidase-based influenza vaccine with bacterial cell membrane-derived adjuvants
NPJ Vaccines. 2025 Jul 10;10(1):149. doi: 10.1038/s41541-025-01209-7.
PMID:
Kirill Vasilev, Irene Hoxie, Eduard Puente-Massaguer, Joshua Yueh, Disha Bhavsar, Maya Singh, Corey P Mallett, Joseph Zimmermann, Florian Krammer
Induction of hemagglutinin stalk reactive antibodies by the administration of a live-attenuated influenza virus vaccine in children
iScience. 2025 Jun 13;28(7):112893. doi: 10.1016/j.isci.2025.112893. eCollection 2025 Jul 18.
PMID:
Juan Manuel Carreño, Philip Meade, Na Fatimata Sogodogo, Kaori Sano, Johnstone Tcheou, Ariel Raskin, Gagandeep Singh, Miriam Fried, Madhumathi Loganathan, Benjamin Francis, Dominika Bielak, Ya Jankey Jagne, Hadijatou J Salah, Florian Krammer, Thushan I de Silva
Exposure to two antigenically distinct SARS-CoV-2 variants broadens neutralization patterns
Vaccine. 2025 Aug 30;62:127459. doi: 10.1016/j.vaccine.2025.127459. Epub 2025 Jul 4.
PMID:
Melanie M Schmitt, Annika Rössler, Antonia Netzl, Ludwig Knabl, Albert Falch, Patrick Neckermann, Marta Bermejo-Jambrina, Wegene Borena, Gagandeep Singh, Florian Krammer, Dorothee von Laer, Ralf Wagner, Derek J Smith, Janine Kimpel
Accomplishments and challenges in developing improved influenza vaccines: An evaluation of three years of progress toward the milestones of the influenza vaccines research and development roadmap
Vaccine. 2025 Aug 13;61:127431. doi: 10.1016/j.vaccine.2025.127431. Epub 2025 Jul 1.
PMID:
Julia T Ostrowsky, Natalie C Vestin, Angela J Mehr, Angela K Ulrich, Lauren Bigalke, Joseph S Bresee, Martin H Friede, Bruce G Gellin, Keith P Klugman, Usman N Nakakana, Tian Yun Wang, Charlotte L Weller, Michael T Osterholm, Eve M Lackritz, Kristine A Moore, Influenza Vaccines R and D Roadmap Taskforce
Phase 2/3 study evaluating safety, immunogenicity, and noninferiority of single booster dose of AVX/COVID-12 vaccine
Sci Adv. 2025 Jun 27;11(26):eadq2887. doi: 10.1126/sciadv.adq2887. Epub 2025 Jun 27.
PMID:
Constantino López-Macías, Martha Torres, Brenda Armenta-Copca, Niels H Wacher, Arturo Galindo-Fraga, Laura Castro-Castrezana, Andrea Alicia Colli-Domínguez, Edgar Cervantes-Trujano, Isabel Erika Rucker-Joerg, Fernando Lozano-Patiño, Juan José Rivera-Alcocer, Abraham Simón-Campos, Efrén Alberto Sánchez-Campos, Rafael Aguirre-Rivero, Alejandro José Muñiz-Carvajal, Luis Del Carpio-Orantes, Francisco Márquez-Díaz, Tania Rivera-Hernández, Alejandro Torres-Flores, Luis Ramírez-Martínez, Georgina Paz-De la Rosa, Oscar Rojas-Martínez, Alejandro Suárez-Martínez, Gustavo Peralta-Sánchez, Claudia Carranza, Esmeralda Juárez, Horacio Zamudio-Meza, Laura E Carreto-Binaghi, Mercedes Viettri, Damaris Romero-Rodríguez