Publications

Functional and epitope specific monoclonal antibody discovery directly from immune sera using cryo-EM

Sci Adv. 2025 Aug 15;11(33):eadv8257. doi: 10.1126/sciadv.adv8257. Epub 2025 Aug 15.

PMID: 

40815640

James A Ferguson, Sai Sundar Rajan Raghavan, Garazi Peña Alzua, Disha Bhavsar, Jiachen Huang, Alesandra J Rodriguez, Jonathan L Torres, Maria Bottermann, Julianna Han, Florian Krammer, Facundo D Batista, Andrew B Ward

From first infection to reinfection: Comparing Nucleocapsid antibody kinetics in vaccinated and unvaccinated adults

Vaccine. 2025 Aug 30;62:127593. doi: 10.1016/j.vaccine.2025.127593. Epub 2025 Aug 13.

PMID: 

40812020

Kathleen M Lindsey, Zachary Farrell, Rebecca Tutino, Theresa Kowalski-Dobson, Zijin Chu, Carmen Gherasim, Shuwei Cai, Gabriel Simjanovski, David Manthei, Emily Stoneman, Florian Krammer, Riccardo Valdez, Aubree Gordon

Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope

Cell Rep. 2025 Aug 26;44(8):116122. doi: 10.1016/j.celrep.2025.116122. Epub 2025 Aug 12.

PMID: 

40803328

Vishal N Rao, Iden A Sapse, Hallie Cohn, Duck-Kyun Yoo, Pei Tong, Jordan J Clark, Bailey Bozarth, Yuexing Chen, Komal Srivastava, Gagandeep Singh, Florian Krammer, Viviana Simon, Duane R Wesemann, Goran Bajic, Camila H Coelho

Molecular organization of the New World arenavirus spike glycoprotein complex

Nat Microbiol. 2025 Sep;10(9):2207-2220. doi: 10.1038/s41564-025-02085-6. Epub 2025 Aug 8.

PMID: 

40781447

Colin J Mann, Pan Yang, Daniel Olal, Xiaoyi Fan, Katherine Nabel Smith, Lars E Clark, Florian Krammer, Yuemin Bian, Jonathan Abraham

A single residue change only differing by an atomic group can drive imprinting to influenza

Res Sq [Preprint]. 2025 Jul 7:rs.3.rs-6914018. doi: 10.21203/rs.3.rs-6914018/v1.

PMID: 

40671817

Jiayi Sun, Gyunghee Jo, Chloe A Troxell, Yanbin Fu, Robert Hoezl, Huibin Lv, Hassanein H Abozeid, Qi Wen Teo, Tossapol Pholcharee, Joshua J C McGrath, Siriruk Changrob, Sean A Nelson, Atsuhiro Yasuhara, Min Huang, Nai-Ying Zheng, Jordan C Chervin, Lei Li, Monica L Fernández-Quintero, Johannes R Loeffler, Alesandra J Rodriguez, Jiachen Huang, Olivia M Swanson, Angel Balmaseda, Guillermina Kuan, Lora Campredon, E Kaitlynn Allen, Gabriele Neumann, Nicholas C Wu, Yoshihiro Kawaoka, Florian Krammer

Integrative mapping of preexisting influenza immune landscapes predicts vaccine response

J Clin Invest. 2025 Jul 15;135(18):e189300. doi: 10.1172/JCI189300. eCollection 2025 Sep 16.

PMID: 

40663396

Stephanie Hao, Ivan Tomic, Benjamin B Lindsey, Ya Jankey Jagne, Katja Hoschler, Adam Meijer, Juan Manuel Carreño Quiroz, Philip Meade, Kaori Sano, Chikondi Peno, André G Costa-Martins, Debby Bogaert, Beate Kampmann, Helder Nakaya, Florian Krammer, Thushan I de Silva, Adriana Tomic

Characterization of the glycoproteins of novel fish influenza B-like viruses

bioRxiv [Preprint]. 2025 May 8:2025.05.08.652883. doi: 10.1101/2025.05.08.652883.

PMID: 

40654808

Gagandeep Singh, Jiachen Huang, Disha Bhavsar, Kirill Vasilev, James A Ferguson, Geert-Jan Boons, Viviana Simon, Robert P de Vries, Julianna Han, Andrew Ward, Florian Krammer

Evaluating Modes of Influenza Transmission (EMIT-2): Insights from a Controlled Human Influenza Virus Infection Transmission Trial (CHIVITT)

medRxiv [Preprint]. 2025 Sep 29:2025.04.28.25326458. doi: 10.1101/2025.04.28.25326458.

PMID: 

40657316

Jianyu Lai, Hamed Sobhani, Kristen K Coleman, S-H Sheldon Tai, Filbert Hong, Isabel Sierra Maldonado, Yi Esparza, Kathleen M McPhaul, Shengwei Zhu, Don L DeVoe, Justin R Ortiz, Shuo Chen, Temima Yellin, Juan Manuel Carreno, Florian Krammer, Benjamin J Cowling, Aubree Gordon, Wilbur H Chen, Jelena Srebric, Donald K Milton

Purification and characterization of recombinant neuraminidase as a potentially broadly protective influenza virus vaccine candidate

Vaccine. 2025 Aug 30;62:127471. doi: 10.1016/j.vaccine.2025.127471. Epub 2025 Jul 11.

PMID: 

40651308

Fernando De Mathia, Tobias Kargl, Matthias Müller, Irfan Erdem, Brooks Hayes, Eduard Puente-Massaguer, Florian Krammer, Nico Lingg

Immunogenicity and protective efficacy of an intranasal neuraminidase-based influenza vaccine with bacterial cell membrane-derived adjuvants

NPJ Vaccines. 2025 Jul 10;10(1):149. doi: 10.1038/s41541-025-01209-7.

PMID: 

40640198

Kirill Vasilev, Irene Hoxie, Eduard Puente-Massaguer, Joshua Yueh, Disha Bhavsar, Maya Singh, Corey P Mallett, Joseph Zimmermann, Florian Krammer
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